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116118 Deng et al found that TMAO may induce neuroinflammation and neuronal apoptosis, leading to NVU dysfunction, which in turn exacerbates cognitive impairment and neuropathological changes in vascular dementia rats

Said et al., 2019

10.22159/ijpps.2017v9i7.17611 3 AfshariH.NooriS.ZarghiA

10.1016/j.redox.2015.07.012 Redox Biol

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Enhanced DRP1 phosphorylation, for instance, causes excessive mitochondrial fragmentation, generating dysfunctional fragments that leak ROS (OH) and mtDNA, activating inflammasomes and apoptotic signals [203]